in vivo ELECTROPHYSIOLOGY

Equipment

• Video Electroencephalography (EEG-video)
• Full bandwidth and DC-coupled recording system
• Event-Related Potential (ERP)
• Electromyography (EMG)

Assays

• Epileptic disorders (presence/type/seizure severity)
• Physiological behaviour (sleep and wake cycles)
• Brain dysfunction (encephalopathy, etc…)
• Study of motor/nerve conduction nerve conduction
• Study of neuromuscular transmission
• Study of spontaneous muscle activity

Highlights

Depdc5 knockout rat: A novel model of mTORopathy. Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S.  Neurobiol Dis. 2016 May;89:180-9. PubMed PMID: 26873552.

Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy. Ribierre T, Deleuze C, Bacq A, Baldassari S, Marsan E, Chipaux M, Muraca G, Roussel D, Navarro V, Leguern E, Miles R, Baulac S. J Clin Invest. 2018 Jun 1;128(6):2452-2458. PubMed PMID: 29708508.

Services

• Generation of full data set: experimental design, data acquisition and analysis
• Training
• Development of new assays on demand